Overexpression of lncRNA PANDAR predicts adverse prognosis in acute myeloid leukemia

Overexpression of lncRNA PANDAR predicts adverse prognosis in acute myeloid leukemia

Abundant studies have shown that lncRNA plays an oncogenic role in human solid tumors. Although abnormal expression of has been well investigated in solid tumors, it was rarely studied in hematologic diseases. Hence, the aim of this study was to determine the expression level and its clinical signif...

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Veröffentlicht in:Cancer management and research 2018-01, Vol.10, p.4999-5007
Hauptverfasser: Yang, Lan, Zhou, Jing-Dong, Zhang, Ting-Juan, Ma, Ji-Chun, Xiao, Gao-Fei, Chen, Qin, Deng, Zhao-Qun, Lin, Jiang, Qian, Jun, Yao, Dong-Ming
Format: Artikel
Sprache:eng
Schlagworte:
Acute myelocytic leukemia
acute myeloid leukemia
Analysis
Antisense RNA
Cancer research
Chromosomes
Explosions
Hematologic diseases
Keywords: long non-coding RNA
Medical research
Myeloid leukemia
Original Research
overall survival
PANDAR
Polymerase chain reaction
Prognosis
Regression analysis
Risk factors
RNA
Tumors
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Zusammenfassung:Abundant studies have shown that lncRNA plays an oncogenic role in human solid tumors. Although abnormal expression of has been well investigated in solid tumors, it was rarely studied in hematologic diseases. Hence, the aim of this study was to determine the expression level and its clinical significance in patients with acute myeloid leukemia (AML). For detecting the expression level of in 119 AML patients and 26 controls, real-time quantitative PCR was used in this study. The prognostic values were evaluated by using Kaplan-Meier analysis, Cox regression analyses, and logistic regression analysis. was significantly overexpressed in AML and might be a promising biomarker which could distinguish AML from normal samples (
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S180150