Clinicopathological and Molecular Characteristics of Pleomorphic Invasive Lobular Carcinoma

Clinicopathological and Molecular Characteristics of Pleomorphic Invasive Lobular Carcinoma

Pleomorphic invasive lobular carcinoma (PILC) is a distinct morphological and biologically aggressive variant of invasive lobular carcinoma (ILC). We hypothesized that was due to de novo activation of PI3K/Akt/mTOR pathway in PILC resulting in higher proliferation rate and markers of cell cycle acti...

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Veröffentlicht in:International journal of breast cancer 2020, Vol.2020 (2020), p.1-7
Hauptverfasser: Chalasani, Pavani, LeBeau, Lauren, Nagle, Raymond, Farr, Kiah J., Pandey, Ritu, Segar, Jennifer M., Gonzalez, Victor J.
Format: Artikel
Sprache:eng
Schlagworte:
1-Phosphatidylinositol 3-kinase
AKT protein
Analysis
Archives & records
Breast cancer
Cancer
Carcinoma
Cell activation
Cell cycle
DNA damage
DNA repair
Estrogens
Gene expression
Genes
Hypotheses
Immunohistochemistry
Invasiveness
Kinases
Lymphatic system
Medical records
Metastasis
Monoclonal antibodies
Pathology
Protein expression
Proteins
PTEN protein
TOR protein
Tumors
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Zusammenfassung:Pleomorphic invasive lobular carcinoma (PILC) is a distinct morphological and biologically aggressive variant of invasive lobular carcinoma (ILC). We hypothesized that was due to de novo activation of PI3K/Akt/mTOR pathway in PILC resulting in higher proliferation rate and markers of cell cycle activation. We identified PILC and ILC tumors and tested for PI3K/Akt/mTOR pathway activation by immunohistochemistry (PTEN and pS6K1) and gene expression analysis (by Nanostring nCounter system). Proliferation index (Ki67) was elevated in 85% of PILCs compared to 20% of ILCs (p
ISSN:2090-3170
2090-3189
2090-3189
DOI:10.1155/2020/8816824