Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Here we describe the use of a new open-source software package and a Raspberry Pi(®) computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide - a component of Rifater(®), used in the trea...

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Veröffentlicht in:Beilstein journal of organic chemistry 2014-03, Vol.10 (1), p.641-652
Hauptverfasser: Ingham, Richard J, Battilocchio, Claudio, Hawkins, Joel M, Ley, Steven V
Format: Artikel
Sprache:eng
Schlagworte:
automation
Chemistry
flow chemistry
Full Research Paper
hydration
hydrogenation
sustainable processing
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Beschreibung
Zusammenfassung:Here we describe the use of a new open-source software package and a Raspberry Pi(®) computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide - a component of Rifater(®), used in the treatment of tuberculosis - and its reduced derivative piperazine-2-carboxamide.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.10.56