Histone crotonylation in neurobiology: to be or not to be?

In a follow-up study by the same group, the authors described the dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development. [...]crotonate is a metabolite of the gut microbe and contributes to histone crotonylation[12]; it would be interesting to investigate the relevance of crotonate and histone crotonylation to the gut-brain axis and gut-mediated brain health and diseases. [...]recent studies on the role of histone crotonylation in neurobiology will certainly stimulate future research and open new avenues for therapeutic advancement in neurobiology. Xiaoqiang Tang, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaE-Mail: tangxiaoqiang@scu.edu.cn; txiaoqiang@yeah.net How to cite this article: