Single‐cell RNA sequencing of pediatric renal tissues revealed the potential relationship between immunoglobulin A nephropathy and immunoglobulin A vasculitis with nephritis

Initially, a comprehensive analysis of the average gene expression profiles was conducted for the IgAN and IgAVN groups in comparison to those in the control group (Figure 1C,D). Using Gene Ontology (GO) analysis, we found that the downregulated DEGs unique to IgAN in PT cells (Figure 2G, section “a”) were predominantly associated with energy metabolism processes (Figure 2I). [...]scRNA-seq analysis of children's kidney samples has pinpointed notable disparities between IgAN and IgAVN, including defects in energy metabolism, variations in HIF1A gene expression, and heightened fibrosis levels in IgAN patients, offering more in-depth data on the single-cell transcriptome regarding the relationship between IgAN and IgAVN, potentially influencing future diagnostic approaches, treatment options, and predictive outcomes for patients with these conditions. Material preparation, data collection and analysis were performed by Qing Ye, Hanyan Meng, Fang Ye, Haidong Fu, Jingjing Wang, Fei Liu, Huijun Shen, Yu Bao Chunyue Feng, Xiaojing Zhang, Guoping Huang, Yi Xie and Manli Zhao.