A new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect transistor

A silicon nanowire field effect transistor biosensor has four advantages in the detection of small biomolecules. It is mark-free, immediately responsive, highly sensitive, and specific. However, because of environments with a high salt concentration, the Debye screening effect has been a major issue in biological detection. To overcome Debye screening effect, realize the clinical application of silicon nanowire field effect transistor and verify its specificity and sensitivity. The test solution was desalted by miniature blood dialyzer, and then the tumor markers were detected by silicon nanowire field effect transistor. Tumor markers in serum were detected successfully and their sensitivity and specificity were verified. This method was found to effectively promote the development of semiconductor materials in biological solution detection.