Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions

Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activi...

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Veröffentlicht in:	Journal of Immunology Research 2015-01, Vol.2015 (2015), p.1-9
Hauptverfasser:	Hewson, R., Bruce, C. B., Schlunegger, K., Empig, C., Corbin-Lickfett, K., Graham, V. A., Dowall, S. D., Easterbrook, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - immunology Antibodies, Viral - metabolism Antiviral agents Apoptosis Cancer therapies Cell Line Cells, Cultured Cercopithecus aethiops Chemical properties Clinical trials Complications and side effects Cytotoxicity Dosage and administration Ebola virus Ebolavirus - immunology Ebolavirus - metabolism Fatalities Flow Cytometry Fluorescent Antibody Technique Genetic aspects Hemorrhagic Fever, Ebola - immunology Hemorrhagic Fever, Ebola - virology Humans Immune system Immunology Infections Laboratories Phosphatidylserines - immunology Phosphatidylserines - metabolism Physiological aspects Protein Binding - immunology Proteins Regulatory approval Vero Cells Viral infections Virion - immunology Virion - metabolism
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Zusammenfassung:	Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity. Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells. Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus.
ISSN:	2314-8861 2314-7156
DOI:	10.1155/2015/347903