Antibacterial and cytotoxic potency of the plant-mediated synthesis of metallic nanoparticles Ag NPs and ZnO NPs: A review

Green synthesis approaches of metal nanoparticles and metal oxide nanoparticles from plant extracts have become a focus of research attention in an era of environmentally friendly development due to the simplicity, low cost, and benefits of environmental sustainability compared to chemical and physical routes. This current review article introduces data from 85 selected articles that were synthesized of ZnO NPs and Ag NPs using the extracts of different plant parts (such as leaves, fruits, flowers, stems, bark, rhizomes, roots, and seeds), with a specific focus on their biomedical applications are 40 selected data of antibacterial properties and the mechanism of action .in addition to 40 selected data of anticancer potential and the mechanism of anticancer (in vitro) at a time or dose-independent using MTT assay and 5 studies (in vivo). Several studies have used different model cell lines to exhibit the cytotoxicity of ZnONPs and AgNPs. Different studies have proved that particle size and shape is a significant factor that indicates the antimicrobial and anticancer effectiveness of NPs. Our results showed that the synthesized ZnO NPs and Ag-NPs using plant extracts display excellent antibacterial and anticancer properties for both metal/metal oxide nanoparticles due to their biocompatibility.