Kidney Transplantation in Kazakhstan: 10-Year Single Center Experience

•Clinical outcomes of first 416-kidney transplantation at a single center in Kazakhstan.•Clinical outcomes are steadily improving•Chronic glomerulonephritis is the major cause of ESRD in our center•The proportion of living donor kidney transplantations is higher compare to deceased donor kidney transplantation Kidney transplantation is considered the best available treatment option for patients with end-stage renal disease (ESRD).In the last decade, organ transplantation has been actively developing in Kazakhstan. Several transplant centers have been opened in 3 regions of Kazakhstan. Here we present the first report of 10-year experience of kidney transplantation in our center. Clinical data of the 416 cases of LDKT and DDKT from 2010 to 2020 were collected from electronic records. All data were retrospectively analyzed. Among 416 kidney transplantations, 56 DDKT and 360 LDKT have been performed in our center from 2010 to 2020. The mean age of the recipient was 37.±12.5; 35.8 % female; 53.7% male. Chronic glomerulonephritis was the most common cause of renal failure in recipients (319 cases; 77%). The overall patient survival rates for 1, 3,5 years were 98.31 %; 97.97 %; 97.52 % respectively for kidney transplantation from a living donor and 98.18 % for all years from a deceased donor. The 1, 3, 5 and 7-year graft survival was 96.26%, 89.47%, 86.58% and 51.95% for the group from a deceased donor, while for the living donor group it was 97.46%, 96.84%, 95.96% and 92.85% respectively. Our clinical outcomes were comparable to other transplant centers in Kazakhstan. However, the proportion of deceased donor kidney transplants and highly sensitized recipients is very low. We believe that with a highly qualified multidimensional transplant team and improved protocols of donor and recipient selection, our center can improve our results and diminish the complications after transplantation.