Influence of fixed-dose combination perindopril/amlodipine on target organ damage in patients with arterial hypertension with and without ischemic heart disease (results of EPHES trial)

Influence of fixed-dose combination perindopril/amlodipine on target organ damage in patients with arterial hypertension with and without ischemic heart disease (results of EPHES trial)

The EPHES trial (Evaluation of influence of fixed dose combination Perindo-pril/amlodipine on target organ damage in patients with arterial HypErtension with or without iSchemic heart disease) compared the dynamics of target organ damage (TOD) in hypertensive patients with and without ischemic heart...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Vascular health and risk management 2018-01, Vol.14, p.265-278
Hauptverfasser: Radchenko, Ganna D, Mushtenko, Liliya O, Sirenko, Yuriy M
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Amlodipine - adverse effects
Amlodipine - therapeutic use
Angina pectoris
Angiotensin-Converting Enzyme Inhibitors - adverse effects
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Antihypertensive Agents - adverse effects
Antihypertensive Agents - therapeutic use
arterial hypertension
Arterial Pressure - drug effects
Blood pressure measurement
Calcium Channel Blockers - adverse effects
Calcium Channel Blockers - therapeutic use
Care and treatment
Combination drug therapy
Comparative analysis
Dosage and administration
Drug Combinations
Echocardiography
Electrocardiography
Female
fixed-dose combination
Health aspects
Heart diseases
Heart hypertrophy
Heart rate
Humans
Hypertension - complications
Hypertension - diagnosis
Hypertension - drug therapy
Hypertension - physiopathology
Hypertrophy
Indapamide
Ischemia
ischemic heart disease
Male
Middle Aged
Myocardial ischemia
Myocardial Ischemia - complications
Myocardial Ischemia - diagnosis
Myocardial Ischemia - physiopathology
Original Research
Perindopril
Perindopril - adverse effects
Perindopril - therapeutic use
target organ damage
Time Factors
Treatment Outcome
Ukraine
Wave propagation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The EPHES trial (Evaluation of influence of fixed dose combination Perindo-pril/amlodipine on target organ damage in patients with arterial HypErtension with or without iSchemic heart disease) compared the dynamics of target organ damage (TOD) in hypertensive patients with and without ischemic heart disease (IHD) treated with the fixed-dose combination (FDC) perindopril + amlodipine. The analysis included 60 hypertensive patients (aged >30 years): 30 without IHD and 30 with IHD. At randomization, FDC was administered at a daily baseline dose of 5/5 mg with uptitration to 10/10 mg every two weeks. If target blood pressure (BP
ISSN:1178-2048
1176-6344
1178-2048
DOI:10.2147/VHRM.S163608