MCM-2 Levels as a Potential Biomarker for Predicting High-Risk Breast Cancer Patients According to TAILORx Classification

MCM-2 Levels as a Potential Biomarker for Predicting High-Risk Breast Cancer Patients According to TAILORx Classification

Background: The minichromosome maintenance protein-2 (MCM-2) is a more sensitive proliferation marker than Ki-67. This study aimed to evaluate the relationship between MCM-2 and Oncotype DX recurrence score (ODX-RS) and determine an MCM-2 cutoff value in high-risk patients according to TAILORx risk...

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Veröffentlicht in:Breast cancer targets and therapy 2023-09, Vol.15, p.659-669
Hauptverfasser: Unal, Caglar, Ozmen, Tolga, Ilgun, Ahmet Serkan, Ordu, Cetin, Ozkurt, Enver, Ak, Naziye, Alco, Gul, Iyigun, Zeynep Erdogan, Kurt, Sevgi, Duymaz, Tomris, Ozturk, Mehmet Alper, Celebi, Filiz Elbuken, Yararbas, Kanay, Soybir, Gursel, Aktepe, Fatma, Ozmen, Vahit
Format: Artikel
Sprache:eng
Schlagworte:
Adjuvant treatment
Breast cancer
Cancer
Cancer patients
Formaldehyde
mcm-2
Oncology, Experimental
oncotype dx recurrence score
Original Research
Progesterone
Risk factors
tailorx risk categorization
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Zusammenfassung:Background: The minichromosome maintenance protein-2 (MCM-2) is a more sensitive proliferation marker than Ki-67. This study aimed to evaluate the relationship between MCM-2 and Oncotype DX recurrence score (ODX-RS) and determine an MCM-2 cutoff value in high-risk patients according to TAILORx risk categorization. Methods: Hormone receptor (HR) positive HER-2 negative early-stage breast cancer patients (pT1-2, pN0-N1, M0) who had ODXRS were included in the study. According to the TAILORx trial, patients were divided into two groups with high (ODX- RS [greater than or equal to] 26) and low risk (ODX-RS
ISSN:1179-1314
1179-1314
DOI:10.2147/BCTT.S421535