FMRI activation to cannabis odor cues is altered in individuals at risk for a cannabis use disorder

Introduction The smell of cannabis is a cue with universal relevance to cannabis users. However, most cue reactivity imaging studies have solely utilized visual images, auditory imagery scripts, or tactile cues in their experiments. This study introduces a multimodal cue reactivity paradigm that includes picture, odor, and bimodal picture + odor cues. Methods Twenty‐eight adults at risk for cannabis use disorder (CUD; defined as at least weekly use and Substance Involvement Score of ≥4 on the Cannabis sub‐test of the Alcohol, Smoking and Substance Involvement Screening Test) and 26 cannabis‐naive controls were exposed to cannabis and floral cues during event‐related fMRI. Between‐group differences in fMRI activation and correlations were tested using FMRIB’s Local Analyses of Mixed Effects and corrected for multiple comparisons using a voxelwise threshold of z > 2.3 and a corrected cluster threshold of p