VEGF Expression to Support Targeted Therapy in Ovarian Surface Epithelial Neoplasms

Vascular Endothelial Growth Factor (VEGF), a promoter of angiogenesis, is a promising target for anti-angiogenic therapy in ovarian cancer. In our study, we examined the expression of VEGF in the spectrum of epithelial ovarian neoplasms (benign, borderline and malignant) by Immunohistochemistry (IHC...

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Veröffentlicht in:Journal of clinical and diagnostic research 2017-04, Vol.11 (4), p.EC43-EC46
Hauptverfasser: Mukherjee, Sudeshna, Pal, Mallika, Mukhopadhyay, Susmita, Das, Indranil, Hazra, Rathin, Ghosh, Suman, Mondal, Rajib Kumar, Bal, Runa
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Sprache:eng
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Zusammenfassung:Vascular Endothelial Growth Factor (VEGF), a promoter of angiogenesis, is a promising target for anti-angiogenic therapy in ovarian cancer. In our study, we examined the expression of VEGF in the spectrum of epithelial ovarian neoplasms (benign, borderline and malignant) by Immunohistochemistry (IHC). Diagnosing ovarian epithelial neoplasms, examining the expression of VEGF in benign, borderline and malignant neoplasms and correlating it with histological grade and stage of malignant cases. This is a cross-sectional, observational study where, total of 50 cases of surface epithelial ovarian neoplasms were examined for expression of VEGF by IHC. Scoring for VEGF expression was done for each case. A total of 42 of the 50 cases (84%) showed VEGF expression. Out of the 42 positive cases, 19 were high VEGF expressors and 23 were low VEGF expressors. VEGF expression was significantly higher in carcinomas as compared to benign and borderline neoplasms (p=
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2017/24670.9737