Improving the effectiveness of treatment of patients with metabolic syndrome by the use of selenium and vitamin complex Oxylyc

Background. Metabolic syndrome (MS) affects about a quarter of the world population and is accompanied by abdominal obesity and insulin resistance, which are the factors of dyslipi­demia, hypertension and hyperglycemia. Nonthyroidal illness syndrome affects about 75 % of hospitalized patients and is accompanied by peripheral hypothyroidism due to inhibition of peripheral conversion of thyroid hormones. Due to the fact that about 80 % of thyroid hormones are produced in peripheral organs, and they regulate almost all processes in the body, the pathological changes that accompany nonthyroidal illness syndrome can be regarded significant. However, the effectiveness of vitamin complexes in combination with selenium in treatment of MS remains unknown. The purpose of the research was to study the effectiveness of Oxylyc in the comprehensive treatment of disorders of carbohydrate, lipid metabolism, endothelial function, antioxidant system, thyroid homeostasis in patients with metabolic syndrome. Materials and me­thods. Sixty-five patients were enrolled to the study. All patients were previously diagnosed with metabolic syndrome. To assess the effectiveness of treatment, patients were randomized into two groups. Patients of the first group (30 people) received Oxylyc — one capsule for 1 month on the background of basic treatment. Representatives of the second group (35 people) received basic treatment. Results. Additional administration of Oxylyc in treatment of patients with MS for 1 month leads to a significant improvement in the sensitivity of receptors to insulin, which is reflected in a decrease in HOMA-IR, indicators of the functional state of the endothelium (decreased production of vascular endothelial growth factor, and desquamation of endothelium), lipid metabolism (decrease in cholesterol, increase in high density lipoproteins and decrease in athe­rogenic coefficient, decrease in the titer of the free thyroxine (fТ4), increase in the free triiodothyronine (fТ3) and the ratio of fT3/fT4, which indicates an improvement of the peripheral conversion of thyroid hormones). Conclusions. Oxylyc can be recommended in comprehensive treatment of metabolic syndrome.