Predictors of Local Invasion in Infiltrative Basal Cell Carcinoma: Tumour Budding Outperforms the WHO Subtyping

Tumour budding (TB) correlates with increased local invasion in various neoplasms. Certain basal cell carcinomas (BCCs) exhibit local aggressiveness. Detecting adverse prognostic factors in partial biopsies could aid in identifying cases with heightened local risk. The absolute number of TB (≤ 3 tum...

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Veröffentlicht in:Acta dermato-venereologica 2024-07, Vol.104, p.adv40172
Hauptverfasser: Fernandez-Figueras, Maria Teresa, Perez-Muñoz, Noelia, Puig, Luis, Posada-Caez, Rodolfo, Ballester Victoria, Rosa, Henriquez, Martha, Musulen, Eva
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Sprache:eng
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Zusammenfassung:Tumour budding (TB) correlates with increased local invasion in various neoplasms. Certain basal cell carcinomas (BCCs) exhibit local aggressiveness. Detecting adverse prognostic factors in partial biopsies could aid in identifying cases with heightened local risk. The absolute number of TB (≤ 3 tumour cells) in excision specimens of 271 infiltrative BCCs (0: absent; 1: 1-2 foci; 2: ≥ 3 foci; 3: ≥ 10 foci), the histopathological subtype and depth of infiltration, perineural invasion, and other histological features were evaluated. A significant correlation was found between TB and both depth of infiltration (rho 0.445, p 
ISSN:0001-5555
1651-2057
1651-2057
DOI:10.2340/actadv.v104.40172