Fe3O4@SiO2-NH2 Functionalized Nanoparticles as a Potential Contrast Agent in Magnetic Resonance

The present work proposes a method for the synthesis of a nanoparticle with a superparamagnetic Fe3O4 core coated with SiO2-NH2 by ultrasound-assisted coprecipitation. Additionally, the nanoparticle is functionalized with a microinflammation biomarker peptide, and its effects on the viability of mon...

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Veröffentlicht in:Condensed matter 2024-12, Vol.9 (4), p.49
Hauptverfasser: Betin Bohorquez, Brayan Stick, Saavedra Gaona, Indry Milena, Parra Vargas, Carlos Arturo, Vargas-Sánchez, Karina, Amaya, Jahaziel, Losada-Barragán, Mónica, Rincón, Javier, Llamosa Pérez, Daniel
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Sprache:eng
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Zusammenfassung:The present work proposes a method for the synthesis of a nanoparticle with a superparamagnetic Fe3O4 core coated with SiO2-NH2 by ultrasound-assisted coprecipitation. Additionally, the nanoparticle is functionalized with a microinflammation biomarker peptide, and its effects on the viability of monkey kidney endothelial cells and the Vero cell line were evaluated. The main physicochemical properties of the nanoparticles were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), a vibrating sample magnetometer (VSM), a field emission scanning electron, Scanning Electron Microscopy (SEM), and High-Resolution Transmission Electron Microscopy (HR-TEM). The results showed that the nanoparticles are spherical, with sizes smaller than 10 nm, with high thermal stability and superparamagnetic properties. They also demonstrated cell viability rates exceeding 85% through Magnetic Resonance Imaging (MRI). The results indicate the potential of these nanoparticles to be used as a contrast agent in magnetic resonance to detect mild brain lesions.
ISSN:2410-3896
2410-3896
DOI:10.3390/condmat9040049