Effect of anti-vascular endothelial growth factor on early-stage post-vitrectomy macular edema in patients with proliferative diabetic retinopathy

To investigate the effectiveness of anti-vascular endothelial growth factor (VEGF) therapy on post-vitrectomy macular edema (PVME) and determine the risk factors for PVME recovery. This retrospective study included 179 eyes of 179 patients who underwent pars plana vitrectomy for proliferative diabet...

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Veröffentlicht in:	BMC ophthalmology 2024-09, Vol.24 (1), p.398-6, Article 398
Hauptverfasser:	Zhou, Hantao, Zhang, Jiayu, Guo, Binghua, Lin, Jue, Mei, Jinghao, Deng, Chuying, Wu, Ronghan, Zheng, Qinxiang, Lin, Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acuity Aged Angiogenesis Inhibitors - therapeutic use Anti–vascular endothelial growth factor Bevacizumab - administration & dosage Bevacizumab - therapeutic use Bupivacaine Care and treatment Cytokines Development and progression Diabetes Diabetes mellitus Diabetic macular edema Diabetic retinopathy Diabetic Retinopathy - drug therapy Diabetic Retinopathy - surgery Dropsy Edema Evidence-based medicine Female Follow-Up Studies Humans Intravitreal Injections Macular Edema - diagnosis Macular Edema - drug therapy Macular Edema - etiology Male Mann-Whitney U test Medical research Medicine, Experimental Middle Aged Normal distribution Patients Postoperative Postoperative Complications Proliferative diabetic retinopathy Ranibizumab - administration & dosage Ranibizumab - therapeutic use Regression analysis Retina Retinal detachment Retinopathy Retrospective Studies Risk factors Software Tomography Tomography, Optical Coherence Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Visual Acuity Vitrectomy Vitrectomy - methods
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Beschreibung
Zusammenfassung:	To investigate the effectiveness of anti-vascular endothelial growth factor (VEGF) therapy on post-vitrectomy macular edema (PVME) and determine the risk factors for PVME recovery. This retrospective study included 179 eyes of 179 patients who underwent pars plana vitrectomy for proliferative diabetic retinopathy and developed PVME within 3 months after surgery. Eyes were grouped according to postoperative anti-VEGF treatment. Central retinal thickness (CRT) decreased significantly from baseline to 3-month follow-up in groups with (509.9 ± 157.2 μm vs. 401.2 ± 172.1 μm, P
ISSN:	1471-2415 1471-2415
DOI:	10.1186/s12886-024-03634-z