The Diagnostic, Prognostic, and Therapeutic Potential of Cell-Free DNA with a Special Focus on COVID-19 and Other Viral Infections

Cell-free DNA (cfDNA) in human blood serum, urine, and other body fluids recently became a commonly used diagnostic marker associated with various pathologies. This is because cfDNA enables a much higher sensitivity than standard biochemical parameters. The presence of and/or increased level of cfDN...

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Veröffentlicht in:International journal of molecular sciences 2023-09, Vol.24 (18), p.14163
Hauptverfasser: Hovhannisyan, Galina, Harutyunyan, Tigran, Aroutiounian, Rouben, Liehr, Thomas
Format: Artikel
Sprache:eng
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Zusammenfassung:Cell-free DNA (cfDNA) in human blood serum, urine, and other body fluids recently became a commonly used diagnostic marker associated with various pathologies. This is because cfDNA enables a much higher sensitivity than standard biochemical parameters. The presence of and/or increased level of cfDNA has been reported for various diseases, including viral infections, including COVID-19. Here, we review cfDNA in general, how it has been identified, where it can derive from, its molecular features, and mechanisms of release and clearance. General suitability of cfDNA for diagnostic questions, possible shortcomings and future directions are discussed, with a special focus on coronavirus infection.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241814163