Development of microRNA therapeutics is coming of age

MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	EMBO molecular medicine 2014-07, Vol.6 (7), p.851-864
Hauptverfasser:	van Rooij, Eva, Kauppinen, Sakari
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antimiR Cardiovascular Diseases - genetics Cardiovascular Diseases - therapy EMBO09 EMBO28 Gene Expression Regulation Genetic Therapy Genetic transcription Health aspects Hepacivirus - physiology Hepatitis C Hepatitis C - genetics Hepatitis C - therapy Homeopathy Humans Materia medica and therapeutics MicroRNA MicroRNAs - genetics mimic miRNA Neoplasms - genetics Neoplasms - therapy Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - therapeutic use Review Therapeutics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA‐based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection. Graphical Abstract This review provides an overview of the current strategies for therapeutic modulation of miRNAs and describes selected microRNA therapies which are moving ahead for the treatment of HCV, cardiovascular diseases as well as cancer.
ISSN:	1757-4676 1757-4684
DOI:	10.15252/emmm.201100899