Controlled release of amoxicillin from bacterial cellulose membranes

Bacterial cellulose (BC), a natural polymer with unique physical and mechanical properties, has several applications in the biomedical field, including drug loading and controlled drug delivery. For this study, a Box-Behnken experimental design was employed as a statistical tool to optimize the release of a model drug, amoxicillin, from BC membranes. Independent variables studied were the concentration of the drug (X 1 ), the concentration of glycerol (X 2 ) and the concentration of a permeation enhancer (X 3 ). From the variables studied, drug concentration had the highest effect on drug release. Among the other independent variables, th linear and quadratic X 2 terms, the linear X 3 term and the interaction term X 2 X 3 were found to affect the release of amoxicillin from bacterial cellulose membranes.