Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272

Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272

Three new polyketides, ketidocillinones A-C ( - ), were discovered from the extract of an Antarctica sponge-derived fungus sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound was established by using ECD calculation....

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Veröffentlicht in:Marine drugs 2020-01, Vol.18 (2), p.71
Hauptverfasser: Shah, Mudassir, Sun, Chunxiao, Sun, Zichao, Zhang, Guojian, Che, Qian, Gu, Qianqun, Zhu, Tianjiao, Li, Dehai
Format: Artikel
Sprache:eng
Schlagworte:
Absolute configuration
antarctica sponge-derived fungus
Antibacterial activity
Antibiotics
Chromatography
Coagulase
Drug resistance
Fermentation
Fungi
Metabolites
Methicillin
Microorganisms
Minimum inhibitory concentration
Natural products
NMR
Nuclear magnetic resonance
Penicillium
penicillium sp
Polyketides
Quinones
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Zusammenfassung:Three new polyketides, ketidocillinones A-C ( - ), were discovered from the extract of an Antarctica sponge-derived fungus sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound was established by using ECD calculation. Compounds - can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C ( and ) exhibited potent antibacterial activity against , and MRCNS (methicillin-resistant coagulase-negative ) with MIC values ranging from 1.56 to 25.00 µg/mL.
ISSN:1660-3397
1660-3397
DOI:10.3390/md18020071