The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis

Nucb2 is a multifunctional protein associated with a variety of biological processes. Multiple studies have revealed that Nucb2, and its derivative nesfatin-1, are involved in carcinogenesis. Interestingly, the role of Nucb2/nesfatin-1 in tumorigenesis seems to be dual-both pro-metastatic and anti-m...

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Veröffentlicht in:	International journal of molecular sciences 2021-05, Vol.22 (11), p.5687
Hauptverfasser:	Skorupska, Anna, Lenda, Rafał, Ożyhar, Andrzej, Bystranowska, Dominika
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis biomarker carcinogenesis Carcinogenesis - genetics Carcinogenesis - metabolism Humans Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms - genetics Neoplasms - metabolism nesfatin-1 Nucb2 Nucleobindins - genetics Review tumors
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Beschreibung
Zusammenfassung:	Nucb2 is a multifunctional protein associated with a variety of biological processes. Multiple studies have revealed that Nucb2, and its derivative nesfatin-1, are involved in carcinogenesis. Interestingly, the role of Nucb2/nesfatin-1 in tumorigenesis seems to be dual-both pro-metastatic and anti-metastatic. The implication of Nucb2/nesfatin-1 in carcinogenesis seems to be tissue dependent. Herein, we review the role of Nucb2/nesfatin-1 in both carcinogenesis and the apoptosis process, and we also highlight the multifaceted nature of Nucb2/nesfatin-1.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms22115687