UDP-glucuronosyltransferase promoter polymorphism in Iranian neonates with idiopathic hyperbilirubinemia

UDP-glucuronosyltransferase promoter polymorphism in Iranian neonates with idiopathic hyperbilirubinemia

To determine the association between polymorphism of UGT1A1 gene and idiopathic hyperbilirubinemia in Iranian neonates. Fifty neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) more that 15mg/dl and 50 neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (ST...

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Veröffentlicht in:Acta medica Iranica 2013, Vol.51 (11), p.789-792
Hauptverfasser: Kaveh, Mahbod, Esmailnia, Tahereh, Nayeri, Fatemeh, Nili, Firoozeh, Davari Tanha, Fatemeh, Ghajarzdeh, Mahsa
Format: Artikel
Sprache:eng
Schlagworte:
Female
Glucuronosyltransferase - genetics
Humans
Hyperbilirubinemia
Hyperbilirubinemia - genetics
Idiopathic
Infant, Newborn
Iran
Male
Neonate
Promoter Regions, Genetic
UDP-glucuronosyltransferase gene
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Zusammenfassung:To determine the association between polymorphism of UGT1A1 gene and idiopathic hyperbilirubinemia in Iranian neonates. Fifty neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) more that 15mg/dl and 50 neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) less than 15mg/dl enrolled in this study. Thymine-adenine (TA)  repeats in the promoter region of UGT1A1 gene investigated by means of  polymerase- chain reaction (PCR) DNA sequencing. Demographic characteristics did not differ significantly between groups while STB was higher in case group (17.5±1.9 vs. 10.4±1.8, p value
ISSN:0044-6025
1735-9694