Identification of novel DNA hypermethylation of the adenylate kinase 5 promoter in colorectal adenocarcinoma

Identification of novel DNA hypermethylation of the adenylate kinase 5 promoter in colorectal adenocarcinoma

Adenylate kinase 5 (AK5) belongs to the adenylate kinase family that catalyses reversible phosphate transfer between adenine nucleotides, and it is related to various energetic signalling mechanisms. However, the role of AK5 in colorectal cancer (CRC) has not been reported. In this study, AK5 was si...

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Veröffentlicht in:Scientific reports 2021-06, Vol.11 (1), p.12626-12626, Article 12626
Hauptverfasser: Ahn, Bokyung, Chae, Yang Seok, Lee, Soo Kyung, Kim, Moa, Kim, Hyeon Soo, Moon, Ji Wook, Park, Sun-Hwa
Format: Artikel
Sprache:eng
Schlagworte:
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Adenine
Adenocarcinoma
Adenylate kinase
Cell migration
Colorectal cancer
Colorectal carcinoma
Deoxyribonucleic acid
DNA
DNA methylation
DNA methyltransferase
Gene expression
Humanities and Social Sciences
Metastases
multidisciplinary
Nucleotides
Phosphorylation
Science
Science (multidisciplinary)
Statistical analysis
TOR protein
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Zusammenfassung:Adenylate kinase 5 (AK5) belongs to the adenylate kinase family that catalyses reversible phosphate transfer between adenine nucleotides, and it is related to various energetic signalling mechanisms. However, the role of AK5 in colorectal cancer (CRC) has not been reported. In this study, AK5 was significantly hypermethylated in CRC compared to adjacent normal tissues (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-92147-6