Tumor-induced osteomalacia characterized by “painful knee joint with difficulty in moving”: a case report

Background Tumor-related osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by severe hypophosphatemia and osteomalacia. The diagnosis of TIO can be very difficult because of its nonspecific nature of clinical manifestations. Here we reported a case of young TIO patient with "painful knee joint with difficulty in moving" to improve the clinical diagnosis and treatment levels. Case presentation The patient's clinical features were consistent with TIO. A tumor was successfully located in left tibial by .sup.68Ga-DOTATATE PET/CT, and then was surgically resected. Upon pathologic assessment, the tumor was diagnosed as phosphaturia stromal tumor (PMT) with positive Vim staining. After the surgery, serum phosphate level rapidly recovered and symptoms significantly improved. Conclusion TIO should be considered in patients with chronically hypophosphorus osteomalacia in the setting of no family history. Early removal of the responsible tumors is clinically essential for the treatment, and imaging examination is of great significance for tumor localization. Keywords: Tumor-induced osteomalacia, Fibroblast growth factor-23, Hypophosphatemia, .sup.68Ga DOTATATE PET/CT, Case report