Influence of vitamin D on sarcopenia pathophysiology: A longitudinal study in humans and basic research in knockout mice

Influence of vitamin D on sarcopenia pathophysiology: A longitudinal study in humans and basic research in knockout mice

Background Vitamin D is an essential nutrient in musculoskeletal function; however, its relationship to sarcopenia remains ambiguous, and the mechanisms and targets of vitamin D activity have not been elucidated. This study aimed to clarify the role of vitamin D in mature skeletal muscle and its rel...

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Veröffentlicht in:Journal of Cachexia, Sarcopenia and Muscle Sarcopenia and Muscle, 2022-12, Vol.13 (6), p.2961-2973
Hauptverfasser: Mizuno, Takafumi, Hosoyama, Tohru, Tomida, Makiko, Yamamoto, Yoko, Nakamichi, Yuko, Kato, Shigeaki, Kawai‐Takaishi, Minako, Ishizuka, Shinya, Nishita, Yukiko, Tange, Chikako, Shimokata, Hiroshi, Imagama, Shiro, Otsuka, Rei
Format: Artikel
Sprache:eng
Schlagworte:
Age
Alcohol use
Alfacalcidol
Animals
Calcifediol
Female
Humans
Longitudinal Studies
Male
Mice
Mice, Knockout
Muscle mass
Muscle strength
Muscles
Musculoskeletal system
Original
Questionnaires
Receptors, Calcitriol
Sarcopenia
Sarcopenia - epidemiology
Sarcopenia - genetics
Seasons
Tamoxifen
Vitamin D
Vitamin D deficiency
Vitamin D Deficiency - complications
Vitamin D Deficiency - metabolism
Vitamin deficiency
Vitamins
Walking
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Zusammenfassung:Background Vitamin D is an essential nutrient in musculoskeletal function; however, its relationship to sarcopenia remains ambiguous, and the mechanisms and targets of vitamin D activity have not been elucidated. This study aimed to clarify the role of vitamin D in mature skeletal muscle and its relationship with sarcopenia. Methods This epidemiological study included 1653 community residents who participated in both the fifth and seventh waves of the National Institute for Longevity Sciences, Longitudinal Study of Aging and had complete background data. Participants were classified into two groups: vitamin D‐deficient (serum 25‐hydroxyvitamin D 
ISSN:2190-5991
2190-6009
DOI:10.1002/jcsm.13102