Comparison of faecal protein biomarkers' diagnostic accuracy for colorectal advanced neoplasms: a systematic review and meta-analysis

Early diagnosis of colorectal advanced neoplasms (ANs), including colorectal cancer (CRC) and advanced adenoma (AA), has a positive effect on the survival rate. As a first attempt, the aim of this meta-analysis was to compare the diagnostic accuracy of faecal protein biomarkers for the detection of...

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Veröffentlicht in:	Scientific reports 2022-02, Vol.12 (1), p.2623-2623, Article 2623
Hauptverfasser:	Nasir Kansestani, Atefeh, Zare, Mohammad Erfan, Tong, Qingchao, Zhang, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 631/67 692/4020 692/4028 Accuracy Adenoma Adenoma - diagnosis Adult Aged Biomarkers Biomarkers - analysis Biomarkers, Tumor - analysis Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Diagnosis Early Detection of Cancer - methods Enzyme-Linked Immunosorbent Assay Feces - chemistry Female Humanities and Social Sciences Humans Leukocyte L1 Antigen Complex - analysis Male Meta-analysis Middle Aged multidisciplinary Occult Blood Pyruvate kinase Pyruvate Kinase - analysis Pyruvic acid Science Science (multidisciplinary) Sensitivity and Specificity Survival Tumors
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Zusammenfassung:	Early diagnosis of colorectal advanced neoplasms (ANs), including colorectal cancer (CRC) and advanced adenoma (AA), has a positive effect on the survival rate. As a first attempt, the aim of this meta-analysis was to compare the diagnostic accuracy of faecal protein biomarkers for the detection of colorectal neoplasms with consideration of a wide range of covariates. A systematic literature search was performed up to Jun 10, 2021 on Web of Sciences, Scopus and PubMed. The diagnostic accuracies were calculated using the bivariate/hierarchical random effect model. Biomarkers were determined to be clinically applicable (CA) if they had areas under the curve > 0.70 and positive and negative likelihood ratios > 2 and
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-06689-4