Multiresistant Fusarium Pathogens on Plants and Humans: Solutions in (from) the Antifungal Pipeline?
The fungal genus contains numerous plant pathogens causing considerable economic losses. In addition, species are emerging as opportunistic human pathogens causing both superficial and systemic infections. Appropriate treatment of infections in a clinical setting of neutropenia is currently not avai...
Gespeichert in:
Veröffentlicht in: | Infection and drug resistance 2019-01, Vol.12, p.3727-3737 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | The fungal genus
contains numerous plant pathogens causing considerable economic losses. In addition,
species are emerging as opportunistic human pathogens causing both superficial and systemic infections. Appropriate treatment of
infections in a clinical setting of neutropenia is currently not available. ESCMID and ECMM joint guidelines, following the majority of published studies, suggest early therapy with amphotericin B and voriconazole, in conjunction with surgical debridement and reversal of immunosuppression. In this review, we elaborate on the trans-kingdom pathogenicity of
. Intrinsic resistance to several antifungal drugs and the evolution of antifungal resistance over the years are highlighted. Recent studies present novel compounds that are effective against some pathogenic fungi including
. We discuss the robust and dynamic antifungal pipeline, including results from clinical trials as well as preclinical data that might appear beneficial for patients with invasive fusariosis. |
---|---|
ISSN: | 1178-6973 1178-6973 |
DOI: | 10.2147/IDR.S180912 |