First report of metallo-β-lactamases producing Enterobacter spp. strains from Venezuela

Clinical strains of Enterobacter were isolated from Cumana's Central Hospital in Venezuela, and classified as E. cloacae (21), E. aerogenes (7), E. intermedium (1), E. sakazakii (1) and three unclassified. The strains showed high levels of resistance, especially to SXT (58.1%), CRO (48.8%), CAZ...

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Veröffentlicht in:	Revista do Instituto de Medicina Tropical de São Paulo 2014-01, Vol.56 (1), p.67-69
Hauptverfasser:	Martínez, Dianny, Rodulfo, Hectorina E, Rodríguez, Lucy, Caña, Luisa E, Medina, Belkis, Guzman, Militza, Carreño, Numirin, Marcano, Daniel, De Donato, Marcos
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics beta-Lactamases - biosynthesis Carbapenemase Carbapenems Cross Infection - microbiology Enterobacter Enterobacter - drug effects Enterobacter - enzymology Enterobacter - genetics Enterobacteriaceae Infections - microbiology Humans Metallobetalactamase Microbial Sensitivity Tests Nosocomial Infections TROPICAL MEDICINE Venezuela VIM
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Zusammenfassung:	Clinical strains of Enterobacter were isolated from Cumana's Central Hospital in Venezuela, and classified as E. cloacae (21), E. aerogenes (7), E. intermedium (1), E. sakazakii (1) and three unclassified. The strains showed high levels of resistance, especially to SXT (58.1%), CRO (48.8%), CAZ (46.6%), PIP (46.4%), CIP (45.2%) and ATM (43.3%). This is the first report for South America of blaVIM-2 in two E. cloacae and one Enterobacter sp., which also showed multiple mechanisms of resistance. Both E. cloacae showed blaTEM-1, but only one showed blaCTX-M-15 gene, while no blaSHV was detected.
ISSN:	0036-4665 1678-9946 1678-9946 0036-4665
DOI:	10.1590/S0036-46652014000100010