Effects of Bemiparin, Dalteparin, and Unfractionated Heparin on Platelet Interaction With Human Subendothelium Under Flow Conditions

We compared the effects of the low-molecular-weight heparin (LMWH), bemiparin, and dalteparin with unfractionated heparin (UFH) on the platelet subendothelium interaction under flow conditions. All three compounds decreased the percentage of subendothelial matrix covered by platelets, although the e...

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Veröffentlicht in:Journal of Pharmacological Sciences 2008, Vol.107(1), pp.103-106
Hauptverfasser: González-Correa, Jose Antonio, Arrebola, María Monsalud, Mérida, Francisco, Navas, María Dolores, López-Villodres, Juan Antonio, Samanes, Felisa, De La Cruz, José Pedro
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Sprache:eng
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Zusammenfassung:We compared the effects of the low-molecular-weight heparin (LMWH), bemiparin, and dalteparin with unfractionated heparin (UFH) on the platelet subendothelium interaction under flow conditions. All three compounds decreased the percentage of subendothelial matrix covered by platelets, although the effect of LMWH was greater than that of UFH. Subendothelial matrix covered with platelet structures greater than 100 square microns was significantly reduced by all three compounds; the effect of bemiparin tended to be greater than that of the other two heparins.
ISSN:1347-8613
1347-8648
DOI:10.1254/jphs.08018SC