Prospective analysis of the effects of RAS mutation on local tumor progression and overall survival after radiofrequency ablation for colorectal liver metastases

To investigate the effects of mutation on local tumor progression (LTP) and overall survival (OS) after radiofrequency ablation (RFA) for colorectal liver metastases (CRLMs). This prospective study consecutively enrolled patients with CRLM who underwent ultrasound-guided RFA between June 2020 and July 2022. mutation status was analyzed via the amplification refractory mutation system PCR method. The safety margin was measured via an anatomic landmark-based manual assessment method. Factors associated with time-to-LTP and OS were assessed via univariate and multivariate analyses. A total of 163 patients with 284 ablated tumors were included. Sixty-nine patients (42.3%) had mutations. Compared with the -wild-type group, the -mutant group had a higher 2-year cumulative LTP rate (20.0% vs. 9.8%, = 0.016) and a worse 2-year OS rate (55.7% vs. 79.8%,