Liposomal nanoparticle-based conserved peptide influenza vaccine and monosodium urate crystal adjuvant elicit protective immune response in pigs

Influenza (flu) is a constant threat to humans and animals, and vaccination is one of the most effective ways to mitigate the disease. Due to incomplete protection induced by current flu vaccines, development of novel flu vaccine candidates is warranted to achieve greater efficacy against constantly...

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Veröffentlicht in:	International journal of nanomedicine 2018-01, Vol.13, p.6699-6715
Hauptverfasser:	Dhakal, Santosh, Cheng, Xingguo, Salcido, John, Renu, Sankar, Bondra, Kathy, Lakshmanappa, Yashavantha Shaan, Misch, Christina, Ghimire, Shristi, Feliciano-Ruiz, Ninoshkaly, Hogshead, Bradley, Krakowka, Steven, Carson, Kenneth, McDonough, Joseph, Lee, Chang Won, Renukaradhya, Gourapura J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - pharmacology Administration, Intranasal Amino Acid Sequence Analysis Animals Antibody Formation - drug effects Antigenic determinants Body Temperature - drug effects Cytokines - biosynthesis Dogs Hogs Immune response Immunity - drug effects Immunity, Mucosal - drug effects Immunoglobulin A Immunologic Memory - drug effects Infection Influenza Influenza A virus peptides Influenza A Virus, H1N1 Subtype Influenza vaccines Influenza Vaccines - immunology Influenza viruses Intranasal vaccination Liposome nanoparticles Liposomes Lung - pathology Lung - virology Madin Darby Canine Kidney Cells Monosodium urate crystal adjuvant Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Original Research Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - virology Pandemics Peptides Peptides - chemistry Peptides - immunology Pigs Sus scrofa Swine flu Swine influenza Swine influenza virus T cells Th1 Cells - drug effects Th1 Cells - immunology Uric Acid - pharmacology Vaccination Vaccines Viral Load - drug effects Viruses
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Beschreibung
Zusammenfassung:	Influenza (flu) is a constant threat to humans and animals, and vaccination is one of the most effective ways to mitigate the disease. Due to incomplete protection induced by current flu vaccines, development of novel flu vaccine candidates is warranted to achieve greater efficacy against constantly evolving flu viruses. In the present study, we used liposome nanoparticle (
ISSN:	1178-2013 1176-9114 1178-2013
DOI:	10.2147/IJN.S178809