Research progress on the role of microRNA in diabetic osteoporosis

Diabetic osteoporosis (DOP) is a common bone metabolic disease in patients with diabetes. Under the high glucose (HG) environment, abnormally expressed microRNA (miRNA) interferes with osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) by regulating key molecules in the Wnt/β...

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Veröffentlicht in:	Ji chu yi xue yu lin chuang = Jichu yixue yu linchuang = Basic medical sciences and clinics 2023-02, Vol.43 (2), p.311-316
1. Verfasser:	YANG Mengdi, DING Yulu, WANG Yujie, HE Fengying, SUN Linnan, ZHEN Donghu
Format:	Artikel
Sprache:	chi
Schlagworte:	diabetes mellitus\|osteoporosis\|micrornas\|wnt signaling pathway\|mesenchymal stem cells
Online-Zugang:	Volltext
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Zusammenfassung:	Diabetic osteoporosis (DOP) is a common bone metabolic disease in patients with diabetes. Under the high glucose (HG) environment, abnormally expressed microRNA (miRNA) interferes with osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) by regulating key molecules in the Wnt/β-catenin signaling pathway, leading to the occurrence and development of DOP. Exploring the role of miRNA in DOP can provide new ideas for the diagnosis and treatment of DOP.
ISSN:	1001-6325
DOI:	10.16352/j.issn.1001-6325.2023.02.311