Endoplasmic reticulum stress and the unfolded protein response in skeletal muscle of subjects suffering from peritoneal sepsis

We provide a descriptive characterization of the unfolded protein response (UPR) in skeletal muscle of human patients with peritoneal sepsis and a sepsis model of C57BL/6J mice. Patients undergoing open surgery were included in a cross-sectional study and blood and skeletal muscle samples were taken...

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Veröffentlicht in:	Scientific reports 2022-01, Vol.12 (1), p.504-504, Article 504
Hauptverfasser:	Metzing, Uta Barbara, von Loeffelholz, Christian, Steidl, Ricardo, Romeike, Bernd, Winkler, René, Rauchfuß, Falk, Settmacher, Utz, Stoppe, Christian, Coldewey, Sina M., Weinmann, Claudia, Weickert, Martin O., Claus, Ralf A., Birkenfeld, Andreas L., Kosan, Christian, Horn, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/250/255 692/4017 692/699 Aged Animals Antigens, CD - genetics Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - genetics Antigens, Differentiation, Myelomonocytic - metabolism Bcl-2 protein Bcl-x protein Cell death Endoplasmic reticulum Endoplasmic Reticulum Stress Female GADD34 protein Humanities and Social Sciences Humans Inflammation Inositol Male Mice Mice, Inbred C57BL Middle Aged mRNA multidisciplinary Muscle, Skeletal - metabolism Musculoskeletal system Patients Peritoneal Diseases - genetics Peritoneal Diseases - metabolism Peritoneal Diseases - physiopathology Peritoneum Protein folding Protein Phosphatase 1 - genetics Protein Phosphatase 1 - metabolism Proteins Science Science (multidisciplinary) Sepsis Sepsis - genetics Sepsis - metabolism Sepsis - physiopathology Skeletal muscle Unfolded Protein Response X-Box Binding Protein 1 - genetics X-Box Binding Protein 1 - metabolism
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Zusammenfassung:	We provide a descriptive characterization of the unfolded protein response (UPR) in skeletal muscle of human patients with peritoneal sepsis and a sepsis model of C57BL/6J mice. Patients undergoing open surgery were included in a cross-sectional study and blood and skeletal muscle samples were taken. Key markers of the UPR and cluster of differentiation 68 (CD68) as surrogate of inflammatory injury were evaluated by real-time PCR and histochemical staining. CD68 mRNA increased with sepsis in skeletal muscle of patients and animals ( p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-04517-9