Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population

Tuberculosis (TB) remains one of the deadliest infectious diseases in the world. Previous genome-wide association studies suggested that single-nucleotide polymorphisms (SNPs) in some genes could indicate the susceptibility to TB in some populations. Herein, we studied the association of SNPs in the...

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Veröffentlicht in:	Journal of immunology research 2022, Vol.2022, p.1-9
Hauptverfasser:	Cui, Xiaogang, Yuan, Tianqi, Ning, Pengyuan, Han, Jie, Liu, Yue, Feng, Jiao, Lian, Fan, Hao, Mingyuan, Dong, Li, Hao, Jinqi, Xing, Li, Wu, Changxin
Format:	Artikel
Sprache:	eng
Schlagworte:	ASAP1 gene Blood & organ donations Cancer Disease Education Genes Genome-wide association studies Genomes Genotyping Immunology Infectious diseases Males Pathogens Population Population genetics Population studies Proteins Risk factors Single-nucleotide polymorphism Statistical analysis Susceptibility Tuberculosis
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Beschreibung
Zusammenfassung:	Tuberculosis (TB) remains one of the deadliest infectious diseases in the world. Previous genome-wide association studies suggested that single-nucleotide polymorphisms (SNPs) in some genes could indicate the susceptibility to TB in some populations. Herein, we studied the association of SNPs in the immunity-related genes, i.e., ASAP1 and SP110 genes with the susceptibility to TB in a Mongolian population in China. A case–control study was performed with 197 TB patients and 217 healthy controls. Six SNPs in ASAP1 and six SNPs in SP110 were selected for genotyping test by second-generation sequencing technique. A SNP in SP110 gene (rs722555) was identified to be associated with susceptibility to TB in the Mongolian population (p
ISSN:	2314-8861 2314-7156
DOI:	10.1155/2022/2713869