Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia

Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Emerging infectious diseases 2003-07, Vol.9 (7), p.864-867
Hauptverfasser:	Nahimana, Aimable, Rabodonirina, Meja, Helweg-Larsen, Jannik, Meneau, Isabelle, Francioli, Patrick, Bille, Jacques, Hauser, Philippe M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS patients Anti-Infective Agents - pharmacology Dihydropteroate Synthase - genetics Dihydropteroate Synthase - metabolism DNA, Fungal - analysis drug pressure drug resistance Drug resistance in microorganisms Drug Resistance, Fungal - genetics Female fungal typing Gene mutations Genetic aspects Genotype Humans Male Middle Aged mutation Mutation - genetics Pneumocystis - drug effects Pneumocystis - genetics Pneumocystis carinii pneumonia Pneumonia, Pneumocystis - drug therapy Pneumonia, Pneumocystis - microbiology Recurrence Sulfonamides - pharmacology Sulfones - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid0907.020753