Differences in red blood cell mass profiles impact intravascular volume and outcome risk in chronic heart failure

Differences in red blood cell mass profiles impact intravascular volume and outcome risk in chronic heart failure

Aims To identify different red blood cell mass (RBCM) profiles, separate from haemoglobin concentrations, and their impact on blood volume expansion and clinical outcomes in chronic heart failure. Methods and results RBCM was measured at hospital discharge using standardized nuclear medicine indicat...

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Veröffentlicht in:ESC Heart Failure 2023-04, Vol.10 (2), p.1270-1279
Hauptverfasser: Miller, Wayne L., Grill, Diane E., Mullan, Brian P.
Format: Artikel
Sprache:eng
Schlagworte:
Anemia
Anemia - complications
Anemia - epidemiology
Blood
Blood Volume
Demographics
Diuretics
Ejection fraction
Electronic health records
Erythrocytes
Heart failure
Heart Failure - therapy
Hemoglobin
Hemoglobins
Hospitalization
Hospitals
Humans
Intravascular volume
Ischemia
Laboratories
Medical records
Mortality
Original
Outcomes
Patients
Plasma
Red blood cell mass
Variables
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Zusammenfassung:Aims To identify different red blood cell mass (RBCM) profiles, separate from haemoglobin concentrations, and their impact on blood volume expansion and clinical outcomes in chronic heart failure. Methods and results RBCM was measured at hospital discharge using standardized nuclear medicine indicator‐dilution methodology in patients following diuretic treatment for clinical congestion. Individual RBCM phenotypes were prospectively identified and analysed for heart failure‐related mortality or first rehospitalization over 1 year. Of 132 patients, 42 (32%) demonstrated normal RBCM, 36 (27%) RBCM deficit (true anaemia), and 54 (41%) RBCM excess (erythrocythemia). Dilutional ‘anaemia’ defined by haemoglobin
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.14309