Kinetics of changes in gene and microRNA expression related with muscle inflammation and protein degradation following LPS-challenge in weaned piglets

To test the dynamic changes of the expression of genes and microRNA in the gastrocnemius muscle after LPS challenge, 36 piglets were assigned to a control group (slaughtered 0 h after saline injection) and LPS groups (slaughtered at 1 h, 2 h, 4 h, 8 h, and 12 h after LPS treatment, respectively). Af...

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Veröffentlicht in:	Innate immunity (London, England) England), 2021-01, Vol.27 (1), p.23-30
Hauptverfasser:	Kang, Ping, Huang, Xingfa, Wan, Zhicheng, Liang, Tianzeng, Wang, Yang, Li, Xiangen, Zhang, Jing, Zhu, Huiling, Liu, Yulan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrophy Cytokines - biosynthesis Cytokines - genetics Degradation Gastrocnemius muscle Gene expression Gene Expression Regulation - genetics IL-1β Inflammation Inflammatory diseases Injection Interleukin 6 Kinetics Lipopolysaccharides Lipopolysaccharides - toxicity Male MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Muscle Proteins - genetics Muscle Proteins - metabolism Musculoskeletal diseases Myositis - genetics Myositis - pathology Nod Signaling Adaptor Proteins - genetics Original Proteins Signal Transduction - genetics Swine TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Tumor necrosis factor-α
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Zusammenfassung:	To test the dynamic changes of the expression of genes and microRNA in the gastrocnemius muscle after LPS challenge, 36 piglets were assigned to a control group (slaughtered 0 h after saline injection) and LPS groups (slaughtered at 1 h, 2 h, 4 h, 8 h, and 12 h after LPS treatment, respectively). After LPS treatment, the mRNA expression of IL-1β, IL-6, and TNF-α reached maximal levels at 1 h, 2 h, and 1 h, respectively (P
ISSN:	1753-4259 1753-4267
DOI:	10.1177/1753425920971032