Galectin-3 not Galectin-9 as a candidate prognosis marker for hepatocellular carcinoma

Galectins (Gal) are a family of protein that bind to the -galactoside of glycoproteins. It modulates a variety of biological functions, such as tumor growth, angiogenesis and tumor metastasis. A series of experimental and clinical evidences have been reported to support a correlation between galecti...

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Veröffentlicht in:PeerJ (San Francisco, CA) CA), 2020-09, Vol.8, p.e9949-e9949, Article e9949
Hauptverfasser: Kong, Fei, Jin, Meishan, Cao, Donghui, Jia, Zhifang, Liu, Yawen, Jiang, Jing
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Sprache:eng
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Zusammenfassung:Galectins (Gal) are a family of protein that bind to the -galactoside of glycoproteins. It modulates a variety of biological functions, such as tumor growth, angiogenesis and tumor metastasis. A series of experimental and clinical evidences have been reported to support a correlation between galectin expressions and neoplastic transformation, progression and prognosis. The objective of this study was to estimate the expression of Gal-3 and Gal-9 in order to evaluate their relation to hepatocellular carcinoma (HCC) -related clinical features and their prognostic values. We evaluated Gal-3 and Gal-9 expression in 247 HCC patients by a tissue microarray immunohistochemistry method, then analyzed the relationship between expression levels of Gal-3 and Gal-9 protein and tumor parameters or clinical outcomes. The Gal-3 expression was significantly higher in tumor tissues compared with adjacent non-tumor tissues (  
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.9949