Fusobacterium nucleatum supresses anti-tumor immunity by activating CEACAM1

) is an oral anaerobe found to be enriched in colorectal cancer (CRC). Presence of in CRC has been correlated with resistance to chemotherapy and poor prognosis. We previously demonstrated that the Fap2 outer-surface protein of binds and activates the human inhibitory receptor TIGIT which is express...

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Veröffentlicht in:Oncoimmunology 2019-06, Vol.8 (6), p.e1581531-e1581531
Hauptverfasser: Gur, Chamutal, Maalouf, Naseem, Shhadeh, Amjad, Berhani, Orit, Singer, Bernhard B, Bachrach, Gilad, Mandelboim, Ofer
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Sprache:eng
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Zusammenfassung:) is an oral anaerobe found to be enriched in colorectal cancer (CRC). Presence of in CRC has been correlated with resistance to chemotherapy and poor prognosis. We previously demonstrated that the Fap2 outer-surface protein of binds and activates the human inhibitory receptor TIGIT which is expressed by T and Natural Killer (NK) cells, and inhibits anti-tumor immunity. Here we show that also binds and activates the human inhibitory receptor CEACAM1 leading to inhibition of T and NK cells activities. Our results suggest that using CEACAM1 and TIGIT inhibitors and specific targeting of fusobacteria should be considered for treating fusobacteria-colonized tumors.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.1080/2162402X.2019.1581531