OXYCARDIN EFFECTS ON HEMOSTASIS AND BLOOD RHEOLOGY IN PATIENTS WITH STABLE ANGINA

The study assessed oxycardin effects on hemostasis and blood rheology in 82 patients with stable angina, Functional Class II-III. In all participants, main parameters of hemostasis, blood viscosity, and red blood cell aggregation and deformation were investigated. Oxycardin course resulted in significantly reduced platelet aggregation, without affecting plasma hemostasis. A reduction in blood viscosity (shift rate 20 s-1) and in platelet aggregation index was also observed. Oxycardin combination with long-term aspirin therapy resulted in further reduction of platelet functional activity. The results obtained confirm oxycardin anti-aggregant activity and its beneficial influence on blood rheology.