Programming of high-glucose diet acceptance in Chinese perch (Siniperca Chuatsi) following an early exposure

•Glucose programming at early stage affect the whole life of fish.•High-glucose stimulation enhanced utilization of carbohydrate in larval Chinese perch.•An early exposure of glucose enhanced acceptance of high-glucose diet.•High-glucose stimulation at early stage change DNA methylation of metabolism genes. As a carnivorous fish, Chinese perch have a poor ability to utilize carbohydrate. To explore the effect of glucose exposure on glucose and lipid metabolism in larval Chinese perch, as well as on the domestication with high-starch artificial diet in juvenile fish. After a short-term glucose immersion, the growth performance, glucose and lipid metabolism, and DNA methylation level of glucose metabolism relative genes were measured. After a 3-month normal feeding trial, the success rate of domestication and the feed intake were examined. Success rate of feed intake and growth performance (the total length, body length and weight) in larval and juvenile fish in GLU group were all significantly higher than CON group (P