Green route synthesis of transition metal doped V2O5 nanoparticles, with emerging biomedical applications

[Display omitted] •Biosynthesis of pristine V2O5, and Ag, Cd and Ru doped V2O5 nanoparticles was synthesized by using vigna radiata extract.•Cd/V2O5 NPs possess high antibacterial activity against S.aureus, S. pneumoniea, P. aeruginosae, K. pneumoniea and E.coli.•The quenching rate constants (kq) values are much bigger than the maximum diffusion constant of biomolecules, 2.0 x 1010M−1s−1. In this proposed work we synthesized the pristine V2O5 nanoparticles and Ag (3.2 % (SV-1), 14.5 %, (SV-5) 23.4 % (SV-9), Cd (5.8 % (CV-1), 23.5 % (CV-5), 35.7 % (CV-9)) and Ru doped (4.9 % (RV-1), 20.7 % (RV-5), 32 % (RV-9)) V2O5 nanoparticles using vigna radiata extract. The nanoparticles were characterized by various techniques like UV-DRS, FT-IR, XRD, FE-SEM and HR-TEM. The antibacterial activities of nanoparticles were studied using bacterial strains such as Staphylococcus aures (S.aureus), Streptococcus pneumoniea (S. pneumoniea), Pseudomonas aeruginosae (P. aeruginosae), Klebsiella pneumoniea (K. pneumoniea) and Escherichia coli (E.coli). Among the nanoparticles the potential bacterium growth inhibition of 99 % for S.aureus was observed for CV-5. The binding efficiency of the nanoparticles with the biomolecule BSA was studied by using UV–visible absorption and emission spectral techniques. It was found that there is a binding interaction between them and the binding constant values are in the range from 104 to 105 M−1. The quenching rate constant (kq) value is bigger than the maximum diffusion constant of biomolecules 2.0 x 1010M−1s−1 suggesting that the interaction is static quenching type. In glucose oxidation studies lower potential with a high current density of 440 mA/cm2 occurred for pristine V2O5 NPs.