The causal relationship between 5 serum lipid parameters and diabetic nephropathy: a Mendelian randomization study

Serum lipids were found to be correlated with chronic kidney disease and cardiovascular disease. Here, we aimed to research the potential causal associations between five serum lipid parameters and the risk of diabetic nephropathy using several Mendelian Randomization methods. Genetic data was obtai...

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Veröffentlicht in:	Frontiers in endocrinology (Lausanne) 2024-05, Vol.15, p.1358358
Hauptverfasser:	Liu, Hongzhou, Yao, Xinxia, Wang, Linlin, Liu, Jia, Li, Xiaojing, Fu, Xiaomin, Liu, Jing, Dong, Song, Wang, Yuhan
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholesterol, HDL - blood Diabetic Nephropathies - blood Diabetic Nephropathies - epidemiology Diabetic Nephropathies - genetics diabetic nephropathy Endocrinology Female Humans instrumental variable lipid Lipids - blood Male Mendelian randomization Mendelian Randomization Analysis Middle Aged Polymorphism, Single Nucleotide Risk Factors serum Triglycerides - blood
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Zusammenfassung:	Serum lipids were found to be correlated with chronic kidney disease and cardiovascular disease. Here, we aimed to research the potential causal associations between five serum lipid parameters and the risk of diabetic nephropathy using several Mendelian Randomization methods. Genetic data was obtained from the UK Biobank datasets. Causal effects were estimated using multiple MR methods. Heterogeneity and pleiotropy tests were performed. MR analysis revealed that HDL-C and TG exhibited causal associations with diabetic nephropathy (
ISSN:	1664-2392 1664-2392
DOI:	10.3389/fendo.2024.1358358