Immunophenotypic profiles and prognosis for colorectal mucinous adenocarcinomas are dependent on anatomic location

Immunophenotypic profiles and prognosis for colorectal mucinous adenocarcinomas are dependent on anatomic location

Background The prognostic value of mucinous adenocarcinomas (MCAs, exhibiting >50% extracellular mucin) of the colorectum, in relation to their anatomic location is not well studied. Materials and Methods We compared MCAs (n = 175) with non‐MCAs (NMCAs, n = 1015) and the cancer‐specific survival...

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Veröffentlicht in:Cancer medicine (Malden, MA) MA), 2023-04, Vol.12 (8), p.9637-9643
Hauptverfasser: Patel, Chirag, Behring, Michael, Al Diffalha, Sameer, Dhall, Deepti, Lee, Goo, Shanmugam, Chandrakumar, Grizzle, William E., Manne, Upender
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma, Mucinous - pathology
Age
Antigens
Bcl-2 protein
Brief Communication
Cancer
Colorectal cancer
Colorectal Neoplasms - pathology
Gender
Humans
Medical prognosis
mucinous adenocarcinomas
Mucins - metabolism
non‐mucinous adenocarcinomas
Pathology
Prognosis
prognostic biomarker
rectal cancers
Rectum
tumor location
Tumor Suppressor Protein p53 - metabolism
Tumors
Variables
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Zusammenfassung:Background The prognostic value of mucinous adenocarcinomas (MCAs, exhibiting >50% extracellular mucin) of the colorectum, in relation to their anatomic location is not well studied. Materials and Methods We compared MCAs (n = 175) with non‐MCAs (NMCAs, n = 1015) and the cancer‐specific survival rates were evaluated, based on their anatomic site, by univariate Kaplan–Meier and multivariate Cox methods. Subsets of these tumors were immunostained for MUC1, MUC2, Bcl‐2, and p53. Results MCAs were more commonly found in the right colon, were of high‐grade, and were more prevalent in younger patients (
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.5803