Prospective memory in prodromal Alzheimer's disease: Real world relevance and correlations with cortical thickness and hippocampal subfield volumes

•Event-based prospective memory is impaired in people with mild cognitive impairment.•Prospective memory mirrors real-world behaviour.•Structural changes in the brain correlate with prospective memory scores.•Different aspects of prospective memory correlate with distinct brain networks.•Prospective memory might be a meaningful measure in clinical practice or research. : Prospective memory (PM) is a marker of independent living in Alzheimer's disease. PM requires cue identification (prospective component) and remembering what should happen in response to the cue (retrospective component). We assessed neuroanatomical basis and functional relevance of PM. 84 older participants (53–94 years old, 58% male) with or without Mild Cognitive Impairment (MCI) performed PM tests, Activities of Daily Living (ADL) scale and had a structural MRI of the brain to estimate for cortical thickness and hippocampal subfield volumes. A General Linear Model cluster analysis was carried out using FreeSurfer to determine which cortical regions were correlated with PM scores. : Both components of PM are impaired in MCI (p