The Role of CLEC-2 and Its Ligands in Thromboinflammation

The Role of CLEC-2 and Its Ligands in Thromboinflammation

C-type lectin-like receptor 2 (CLEC-2, also known as CLEC-1b) is expressed on platelets, Kupffer cells and other immune cells, and binds to various ligands including the mucin-like protein podoplanin (PDPN). The role of CLEC-2 in infection and immunity has become increasingly evident in recent years...

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Veröffentlicht in:Frontiers in immunology 2021-06, Vol.12, p.688643-688643
Hauptverfasser: Meng, Danyang, Luo, Man, Liu, Beibei
Format: Artikel
Sprache:eng
Schlagworte:
CLEC-2
Immunology
inflammation
podoplanin
thromboinflammation
thrombosis
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Zusammenfassung:C-type lectin-like receptor 2 (CLEC-2, also known as CLEC-1b) is expressed on platelets, Kupffer cells and other immune cells, and binds to various ligands including the mucin-like protein podoplanin (PDPN). The role of CLEC-2 in infection and immunity has become increasingly evident in recent years. CLEC-2 is involved in platelet activation, tumor cell metastasis, separation of blood/lymphatic vessels, and cerebrovascular patterning during embryonic development. In this review, we have discussed the role of CLEC-2 in thromboinflammation, and focused on the recent research.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.688643