Sex-specific associations of prenatal exposure to bisphenol A and its alternatives with fetal growth parameters and gestational age

•Prenatal urinary BPA and BPF exposures were associated with reduced birth length and increased ponderal index.•Prenatal urinary BPS exposure was associated with reduced gestational age.•Sex-specific associations of prenatal bisphenol exposures with fetal growth parameters were observed. Bisphenol A...

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Veröffentlicht in:Environment international 2021-01, Vol.146, p.106305, Article 106305
Hauptverfasser: Yang, Pan, Lin, Bi-Gui, Zhou, Bin, Cao, Wen-Cheng, Chen, Pan-Pan, Deng, Yan-Ling, Hou, Jian, Sun, Sheng-Zhi, Zheng, Tong-Zhang, Lu, Wen-Qing, Cheng, Li-Ming, Zeng, Wan-Jiang, Zeng, Qiang
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Sprache:eng
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Zusammenfassung:•Prenatal urinary BPA and BPF exposures were associated with reduced birth length and increased ponderal index.•Prenatal urinary BPS exposure was associated with reduced gestational age.•Sex-specific associations of prenatal bisphenol exposures with fetal growth parameters were observed. Bisphenol A (BPA) can cause detrimental effects on fetal growth. However, the effects of BPA alternatives, such as bisphenol F (BPF) and bisphenol S (BPS), on fetal growth are less known. To investigate the relationships of prenatal BPA, BPF, and BPS exposures with fetal growth parameters and gestational age. Urinary BPA, BPF, and BPS were measured in 1,197 pregnant women before delivery in a Chinese cohort. The associations of prenatal exposure to BPA, BPF, and BPS with fetal growth parameters and gestational age were examined, and associations stratified by fetal sex were also conducted. We used a restricted cubic splines (RCS) model to examine the dose–response associations between exposures and outcomes. Maternal urinary BPA and BPF were negatively related to birth length (-0.30 cm, 95% CI: −0.44, −0.15 and −0.21 cm, 95% CI: −0.36, −0.07 comparing the extreme exposure groups, respectively, both p for trends 
ISSN:0160-4120
1873-6750
DOI:10.1016/j.envint.2020.106305