Antibacterial activity of Ocimum sanctum L. essential oil against multidrug resistance bacteria vaginosis

The antibiotic resistance of Bacteria Vaginosis (BV) isolates intensifies vaginal morbidity and genital infections facilitating poor treatment outcome and severe vaginal pathology. The phytochemicals in Ocimum sanctum essential oil (OsEO) were investigated for their antibacterial activity against bacteria vaginosis and major metabolites on multidrug resistance (MDR) strains. Bacteria pathogens isolated from vaginal samples (n = 40) obtained from patients with confirmed BV were analysed for hemolytic activity, biofilm production and profiled for antibiotic resistance. Extracted OsEO was profiled with GC-MS and analysed for antibacterial activity. Of the recovered bacteria pathogens (n = 241) associated with vaginosis including Streptococcus pyogenes (34 %), Staphylococcus aureus (31 %) and Escherichia coli (10 %) and less than 10 % Klebsiella oxytoca, Enterobacter cloaca, Pseudomonas aeruginosa and Citrobacter freundii were identified. Significant rates of 21.6 %, 4.6 % and 2.3 % were weak, mild and strong biofilm producers respectively and overall 26.6 % were hemolytic strains (p 0.2 (p