Involvement of Substance P and the Neurokinin-1 Receptor in Radiation-Induced Hair Loss in Mice

We investigated the involvement of substance P (SP) and the neurokinin-1 receptor (NK1 R) in the development of radiation-induced hair loss in mice. A dose of 40 Gy of gamma irradiation induced hair loss from the 10th to at least the 60th day after irradiation. A specific NK1R antagonist, CP-99,994,...

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Veröffentlicht in:	Journal of Pharmacological Sciences 2010, Vol.112(1), pp.118-120
Hauptverfasser:	Yamamoto, Kouichi, Kureyama, Naoko, Asano, Keiko, Ikeda, Toshiji, Yamatodani, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alopecia - drug therapy Alopecia - metabolism Animals Male Mice Mice, Inbred C57BL neurokinin-1 receptor Neurokinin-1 Receptor Antagonists Piperidines - pharmacology Piperidines - therapeutic use Protein Precursors - biosynthesis Protein Precursors - radiation effects Radiation Injuries, Experimental - drug therapy Radiation Injuries, Experimental - metabolism radiation-induced hair loss Receptors, Neurokinin-1 - physiology Receptors, Neurokinin-1 - radiation effects substance P Substance P - physiology Substance P - radiation effects Tachykinins - biosynthesis Tachykinins - radiation effects
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Zusammenfassung:	We investigated the involvement of substance P (SP) and the neurokinin-1 receptor (NK1 R) in the development of radiation-induced hair loss in mice. A dose of 40 Gy of gamma irradiation induced hair loss from the 10th to at least the 60th day after irradiation. A specific NK1R antagonist, CP-99,994, significantly delayed radiation-induced hair loss and reduced its severity. Furthermore, gamma irradiation induced the expression of preprotachykinin-A, a precursor protein of SP, mRNA in irradiated murine skin on the 10th and 30th days after irradiation. These results indicated that gamma irradiation-induced hair loss was mediated by SP via NK1R.
ISSN:	1347-8613 1347-8648
DOI:	10.1254/jphs.09256SC